Scleroderma: Scleroderma is a group of diseases, which tightens and hardens the skin, which is the result of this disease. It is an autoimmune disorder, which means a condition in which the immune system attacks the body, hence immune system by mistake destroys the healthy tissues as the immune system thinks it`s a foreign substance or infection. It also affects connective tissues, and many other problems can also be seen due to this disease like affecting the very important system and organs of the body like the digestive system, heart, lungs, and kidneys.